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Nanoparticles are characterized by their small size, large surface area, and possibility of functionalization, which allows them to be useful in many areas, including improved bioavailability, decreased systemic side effects, and improved therapeutic efficacy

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They work well with B12 to improve treatment results

A Phase 1 registry record has no posted efficacy result, and a small uncontrolled knee-pain report does not establish benefit

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Absorption/malabsorption counts : Many b12 deficiencies arise not strictly from inadequate intake, but from malabsorption (e.g., pernicious anaemia, gastrointestinal surgery, vegan diets with long-term low intake)